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The Neurobiology of Addiction Research Center (NARC)

Publications 2012-2013

2013 Publications

NARC Peer-Reviewed Original Research

1. Mahler, SV, M Hensley-Simon, RT LaLumiere, P Tahsili-Fahadan, C Thomas, RJ Fallon, PW Kalivas and G Aston-Jones.  2012.  Modafinil attenuates reinstatement of cocaine-seeking: Role for cystine-glutamate exchange and metabotropic glutamate receptors. Addict Biol, in press.

2. Mahler, S., Smith, R. and Aston-Jones, G., Simultaneous orexin and glutamate neurotransmission in ventral tegmental area is required for cue-induced cocaine seeking Psychopharmacology: DOI 10.1007/s00213-012-2681-5 (2013).

3. Shen H and PW Kalivas. 2012. Reduced LTP and LTD in prefrontal cortex synapses in the nucleus accumbens after heroin self-administration.  Int J Neuropsychopharmacol, in press.

4. Gipson CD, YM Kupchik, H Shen, KJ Reissner, CA Thomas and PW Kalivas. 2013. Relapse induced by cues predicting cocaine depends on rapid, transient synaptic potentiation. Neuron, in press.

5. Wang XS, K Moussawi, HW Shen and PW Kalivas.  2013.  Role of mGluR5 neurotransmission in reinstated cocaine-seeking. Addict Biol, in press.

6. Stefanik MT, K Moussawi, YM Kupchik, KC Smith, RL Miller, ML Huff, K Deisseroth, PW Kalivas and RT LaLumiere.  2012.  Optogenetic inhibition of cocaine seeking in rats.  Addict Biol, in press.

7. LaRowe SD, PW Kalivas, JS Nicholas, PK Randall, PN Mardikian and RJ Malcolm.  2012.  A double-blind placebo-controlled trial of N-acetylcysteine in the treatment of cocaine dependence. Am J Addict, in press.

8. Mahler S.V., Smith R.J., Sartor G.C., Moorman D.E., Aston-Jones G.  2012. Multiple roles for orexin in addiction.  Prog.Brain.Res. In Press

9. Cason, A. and Aston-Jones, G., Role of orexin/hypocretin in conditioned sucrose-seeking in rats. Psychopharmacology DOI 10.1007/s00213-012-2902-y (2013).

10. Sun WL, Coleman NT, Zelek-Molik A, Barry SM, Whitfield, Jr., TW, McGinty JF. Relapse to cocaine-seeking after abstinence Is regulated by cAMP-dependent protein kinase A in the prefrontal cortex. Addiction Biol in press.

11. Sun WL, Zelek-Molik A, McGinty JF. Short and long access to cocaine self-administration attenuates the tyrosine phosphatase STEP and GluN2B phosphorylation but differentially regulates GluA1 and 2 expression in the prefrontal cortex. Psychopharmacol in press.

NARC Peer-Reviewed, Published Reviews

1. Lewerenz J, S Hewett, Y Huang, M Lambros, PW Gout, PW Kalivas, A Massie, I Smolders, A Methner, M Pergande, SB Smith, V Ganapathy and P Maher.  2012.  The cystine/glutamate antiporter system xc- in health and disease:  From molecular mechanisms to novel therapeutic opportunities.  Antiox Redox Signaling, in press.

2. Smith, RJ, MK Lobo, S Spencer and PW Kalivas.  2013.  Cocaine-induced adaptations in D1- or D2-expressing accumbens projection neurons:  Not synonymous with classical direct and indirect pathways.  Curr Op Neurobiol, in press.

NARC Invited Editorials, Perspectives and Chapters

1. Feltenstein MW, See RE 2013. Systems level neuroplasticity in drug addiction.  In: Addiction (Eds. Pierce RC, Kenny PJ), Cold Spring Harbor Perspectives in Medicine, Cold Spring Harbor Laboratory Press; pp. 43-61.

2. Scoffield, MD and PW Kalivas.  2013.  Forgiving the sins of the father.  Nat Neuroscience (News and Views), 16: 4-5.

3. Reissner KJ and PW Kalivas. 2013. Cellular and molecular mechanisms of addiction. In: Neurobiology of Mental Illness, 4th Ed, Oxford University Press.  Eds D Charney, EJ Nestler

4. Aston-Jones G. and Deisseroth, K., Optogenetics and Pharmacogenetics: Revolutions in Neuroscience. Overview of Special Issue on Optogenetics and Pharmacogenetics. Brain Res. (in press).


NARC Peer-Reviewed Original Research

1. Feltenstein MW, Ghee SM, See RE (2012) Nicotine self-administration and reinstatement of nicotine-seeking in male and female rats.  Drug and Alcohol Dependence; 121(3):240-246. PMCID: PMC3258537

2. Trantham-Davidson, H, R LaLumiere, K Reissner, PW Kalivas and LA Knackstedt.  2012.  Ceftriaxone normalizes synaptic transmission, glutamate transport and export following cocaine self-administration and extinction training.  J Neuroscience, 32: 12406-410.

3. Kupchik, YM, K Moussawi, XC Tan, X Wang, BC Kalivas, R Kolokithas, KB Ogburn and PW Kalivas.  2012.  The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine. Biol Psychiat, 71:978-986.

4. LaLumiere RT, KC Smith and PW Kalivas. 2012. Neural circuit competition for control of cocaine seeking:  Role of the infralimbic cortex and nucleus accumbens shell. Eur J Neuroscience, 35: 614-22.

5.  Zhou L, Aston-Jones G, Smith RJ, Do P, See RE. 2012. Repeated orexin 1 receptor antagonism effects on cocaine seeking in rats. Neuropharmacology, 63(7):1201-1207. in press.

6. Smith, R. J. and Aston-Jones, G. 2012. Orexin/hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking. Eur. J. Neuroscience. 35: 798-804.

7. Sartor, G. and Aston-Jones, G., 2012. A septal-hypothalamic pathway drives orexin neurons and cocaine seeking. J. Neurosci. 32: 4623-4631.

8. Richardson, K. and Aston-Jones, G. 2012. Lateral hypothalamic orexin/hypocretin neurons that project to VTA are differentially activated with morphine preference, J. Neurosci. 32: 3209-3817

9. Mahler, S., Smith R. and Aston-Jones, G. 2012. Fos activation of selective afferents to ventral tegmental area during cue-induced reinstatement of cocaine seeking in rats. J. Neurosci., 32:13309-13326.

10. Smith, R.J. and Aston-Jones, G. Alpha-2 adrenergic and imidazoline receptor agonists prevent cue-induced cocaine-seeking. Biol. Psychiat. 70: 712-719 (2012).

11. Reissner, K., Sartor, G., Vazey, E., Dunn, T., Aston-Jones, G. and Kalivas, P., Use of vivo-morpholinos for control of protein expression in the adult rat brain. J. Neurosci. Methods: 203: 354-360 (2012).

12. Zhou, L., Smith, R.J., Do, P.H., Aston-Jones, G. and See, R.E., Chronic orexin 1 receptor antagonism effects on cocaine seeking in rats. Neuropharmacology 63: 1201-1207 (2012).

13. Sartor, G and Aston-Jones, G., Regulation of ventral tegmental area by bed nucleus of the stria terminalis is required for expression of cocaine preference. Europ. J. Neurosci. DOI 10.1111/j.1460-9568.2012.08277.x (2012).

14. Hensley-Simon, M., Mahler, S., LaLumiere, R., Tahsili-Fahadan, P., Thomas, C., Fallon, R., Kalivas, P.W. and Aston-Jones, G.,  Modafinil Attenuates Reinstatement of Cocaine Seeking: Role for Cystine-Glutamate Exchange and Metabotropic Glutamate Receptors. Addiction Biol. DOI 10.1111/j.1369-1600.2012.00506.x (2012).

15. Bentzley, B., Fender, K. and Aston-Jones, G., The behavioral economics of drug self-administration: A review and new analytical approach for within-session procedures. Psychopharmacology 10.1007/s00213-012-2899-2 (2012).

16. Schwendt M, Sigmon SA, McGinty JF. RGS4 over-expression in the rat dorsal striatum modulates mGluR5- and psychostimulant-mediated behavior and signaling. Psychopharmacology 221:621-635, 2012.

NARC Peer-Reviewed, Published Reviews

1. Olive FM, RM Cleva, PW Kalivas and RJ Malcolm.  2012.  Glutamatergic medications for the treatment of drug and behavioral addictions.  Pharmacol Biochem Behav, 100:801-810.  PMID: 21536062

2. Reichel CM, See RE. 2012. Chronic N-acetylcysteine after cocaine self-administration produces enduring reductions in drug-seeking.  Neuropsychopharmacol Rev; 37(1):298

3. Mahler SV, RJ Smith, DE Moorman, GC Sartor and G Aston-Jones.  2012.  Multiple roles for orexin/hypocretin in addiction.  Prog Brain Res, 198: 79-121.

NARC Invited Editorials, Perspectives and Chapters

1. Kalivas PW and KT Brady.  2012.  Hatching the addiction egg.  Nat Med (Bedside to Bench), 18: 502-503.  PMID: 22481410

2. Reissner KJ and PW Kalivas.  2012. Common Mechanisms of Addiction. In: Encyclopedia of Addictive Behaviors. Chapter 141, Academic Press.

3. LaLumiere RT and PW Kalivas.  2012. Motivational Systems: Rewards and Incentive Value. In Weiner, I. (ed). Handbook of Psychology (2nd ed.). Volume 3: Biological Psychology and Neuroscience. (Vol. 3 eds: Nelson, R., and Mizumori, S.). Wiley.

4. Reid AG, AR Lingford-Hughes, L Cancela and PW Kalivas.  2012. Substance abuse disorders, chapter 24. In: Handbook of Clinical Neurology, Vol. 105, Neurobiology of Psychiatric Disorders. Eds TE Schlaepfer and CB Nemeroff, Elsevier

5. Mahler, S., Smith, R., Moorman, D., Sartor, G. and Aston-Jones, G., Multiple roles for orexin/hypocretin in addiction. Prog. Brain Res. 198: 79-121 (2012).

6. Richerson, G., Saper, C. and Aston-Jones, G., The monoamines and brainstem modulatory systems. In: Principles of Neural Science, Kandel, E. et al., eds. (2012).

7. McGinty JF. The many faces of MeCP2. Neuropsychopharmacology 37:313-314, 2012.

8. Schmidt HD, McGinty JF, West AE, and Ghazaleh Sadri-Vakili G. Epigenetics and psychostimulant addiction. Addiction. RC Pierce and PJ Kenny (eds) Cold Spring Harbor Laboratory Press, 2012.

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