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The Neurobiology of Addiction Research Center (NARC)

Publications Archive

2008 2007 2006 2005 2004 2003

2008 Publications

NARC Peer-Reviewed Original Research:

1. Bongiovanni M, See RE (2008) A comparison of the effects of different operant training experiences and dietary restriction on the reinstatement of cocaine-seeking in rats.  Pharmacology, Biochemistry, and Behavior 89(2): 227-233.  PMCID: PMC2267375

2. Samuvel DJ, Jayanthi LD, Manohar S, Kaliyaperumal K, See RE, Ramamoorthy S (2008) Dysregulation of dopamine transporter trafficking and function following prolonged abstinence from cocaine self-administration in rats: Evidence for differential regulation in caudate-putamen and nucleus accumbens. JPET 325(1):293-301.

3. Zhou W and PW Kalivas.  2008.  N-acetylcysteine facilitates extinction and induces enduring reductions in cue- and heroin-induced drug-seeking.  Biol Psychiat, 63: 338-340.

4. Kalivas PW.  2008.  Addiction as a pathology in prefrontal cortical regulation of corticostriatal habit circuitry.  Neurotox Res, 14: 185-190.  PMID: 19073425

5. Peters J, Vallone J, Laurendi K and PW Kalivas. 2008. Opposing roles for the ventral prefrontal cortex and basolateral amygdala on spontaneous recovery of cocaine-seeking. Psychopharmacol, 197: 319-326.

6. Peters J, R LaLumiere and PW Kalivas. 2008. Activity in infralimbic cortex suppresses cocaine relapse. J Neuroscience, 28: 6046-6053.  PMID: 18524910

7. Shen H, S Sesack, S Toda and PW Kalivas.  2008.  Automated quantification of dendritic spine density and spine head diameter in medium spiny neurons. Br Struct Func, 213: 149-158.  PMID: 18675832

8. Hearing MC, Miller SW, See RE, McGinty JF. 2008. Relapse to cocaine seeking increases activity-regulated gene expression differentially in the prefrontal cortex of abstinent rats. Psychopharmacology 198:77-91.

9. Hearing MC, See RE, McGinty JF. 2008.  Relapse to cocaine seeking increases activity-regulated gene expression differentially in the striatum of abstinent rats. Brain Structure & Function 213:215-227.

10. McGinty, JF, Shi XD, Schwendt M, Saylor A, Toda S.  2008. Regulation of psychostimulant-induced signaling and gene expression in the striatum. J Neurochem 104:1440-9. PMCID:PMC3120109

11. Gompf, H. and Aston-Jones, G., 2008. Role of orexin input in the diurnal rhythm of locus coeruleus impulse activity Brain Res. 1224: 43-52.

12. Rogers JL, Ghee S, See RE (2008) The neural circuitry underlying reinstatement of heroin-seeking behavior in an animal model of relapse.  Neuroscience 151(2):579-588.  PMCID: PMC22386881. 

NARC Peer-Reviewed, Published Reviews:

1. Kalivas PW and O’Brien C.  2008.  Addiction as a disease of staged neuroplasticity.  Neuropsychopharm Rev, 33:166-180.

2. Feltenstein MW, See RE (2008) The neurocircuitry of addiction: An overview.  Brit J Pharmacol 154(2):261-274. PMCID:PMC2442446

3. Thomas MJ, PW Kalivas, Y Shaham.  2008.  Neuroplasticity in the mesolimbic dopamine system and cocaine addiction. Brit J Pharmacol, 154: 327-342.

4. Smith, R. J. and Aston-Jones, G., Noradrenergic transmission in the extended amygdala: Role in increased drug-seeking and relapse during protracted drug abstinence. Brain Struc. Func. 213: 43-61 (2008).

NARC Invited Editorials, Perspectives and Chapters:

1. Kalivas PW and H Manji.  2008.  Neuroplasticity in neuropsychiatric disease. Neuropsychopharm Rev (Editorial), 33: 2.

2. Lawrence A, P Beart and PW Kalivas.  2008.  Neuropharmacology of addiction:  Setting the scene. Brit J Pharmacol (Commentary), 154: 259-260.  PMID: 18414384

3. Aston-Jones, G and PW Kalivas.  2008.  Brain norepinephrine rediscovered in addiction research. Biol Psychiat (Commentary), 11: 1005-1006.  PMID: 18482610

4. Carr, D and PW Kalivas.  2008.  Confused about NMDA and addiction?  Targeted knockouts provide answers and new questions.  Neuron (Preview), 59: 353-355.  PMID: 18701061

5. Chandler, J and PW Kalivas.  2008.  Brain’s defense against cocaine.  Nature (News and Views), 455: 743-744.  PMID: 18843354

6. Melendez, R and PW Kalivas.  2008.  Basic science of addiction.  In, Pain and Chemical Dependency, Eds, H Smith and S Passik, Oxford Univ Press, pg 31-38.

7. Mohan A, S Pendyam, G Li, J Gall, PW Kalivas and SS Nair. 2008. Computational models of neuronal networks- Modeling neuroplascitiy in glutamate transmission due to cocaine. In, New Research on Neuronal Networks, Ed. Fran Columbus, Nova Science Publishers, NY, pg 65-107.

8. Kalivas PW. 2008. Glutamate. In, Encyclopedia of Drugs, Alcohol & Addictive Behavior, Eds P Korsmeyer and HR Kranzler, Macmillan Reference, USA, Ed 3.

9. Kalivas PW. 2008. Brain structures and drugs. In, Encyclopedia of Drugs, Alcohol & Addictive Behavior, Eds P Korsmeyer and HR Kranzler, Macmillan Reference, USA, Ed 3.

2007 Publications

Original Research:

Harris, G., Wimmer, M., Randall-Thompson, J and Aston-Jones, G., Lateral hypothalamic orexin neurons are critically involved in learning to associate an environment with morphine reward Behav. Brain Res. 183: 43-51 (2007).

Feltenstein MW, Altar CA, See RE (2007) Aripiprazole blocks reinstatement of cocaine-seeking in an animal model of relapse.  Biological Psychiatry 61(5):582-590.

Rogers JL, See RE (2007) Inactivation of the ventral hippocampus attenuates cue-induced and cocaine-primed reinstatement of drug-seeking in rats.  Neurobiology of Learning and Memory 87:688-692.

Schwendt M, Hearing MC, See RE, McGinty JF (2007) Chronic cocaine reduces RGS4 mRNA in rat prefrontal cortex and dorsal striatum.  Neuroreport 18:1261-1265.

Berglind WJ, See RE, Fuchs RA, Ghee S, Whitfield TW, Miller SW, McGinty JF (2007) A BDNF infusion into the medial prefrontal cortex suppresses cocaine-seeking in rats.  European Journal of Neuroscience 26:757-766.

See RE, Elliott JC,Feltenstein MW (2007) The role of dorsal vs. ventral striatal pathways in cocaine-seeking behavior following prolonged abstinence in rats.  Psychopharmacology 194:321–331.

Feltenstein MW, See RE (2007) NMDA receptor blockade in the basolateral amygdala disrupts consolidation of stimulus-reward memory and extinction learning during reinstatement of cocaine-seeking in an animal model of relapse.  Neurobiology of Learning and Memory 88:435-444.

Bowers MS, Chen BT, Chou JK, Osborne MPH, Gass JT, See RE, Bonci A, Janak PH, Olive MF (2007) Acamprosate attenuates cocaine and cue-induced reinstatement of cocaine-seeking behavior in rats. Psychopharmacology 195:397–406.

Zhou W, J Liu, F Zhang, S Tang, H Zhu, M Lai and PW Kalivas. 2007. Possible role of acetylcholine transmission in nucleus accumbens and ventral tegmental area in heroin-seeking induced by conditioned cues. Neuroscience, 144: 1209-1218.

Knackstedt L and PW Kalivas. 2007. Extended access to cocaine self-administration enhances drug-primed reinstatement but not behavioral sensitization. J Pharmacol Exp Ther, 322: 1103-1109.

Kalivas PW. 2007. Neurobiology of cocaine addiction: Implications for new pharmacotherapy. Am J Addict, 16: 71-78, 2007.

Kalivas PW.  2007.  Cocaine and amphetamine-like psychostimulants: neurocircuitry and glutamate neuroplasticity. Dialogues Clin Neuro 9: 167-175.

Chapters in Books and Editorials:

McGinty JF. Co-localization of GABA with other neuroactive substances in the basal ganglia. GABA and the Basal Ganglia. From Molecules to Systems. Progress in Brain Research 160. Tepper JM, Abercrombie ED,  Bolam JP (eds). Elsevier  2007; 273-284.

Toda, S and PW Kalivas. 2007. Research in addiction as chronic and progressive mental disorder involving metaplasticity.  Cell Biol, 26: 2-7.

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2006 Publications

Original Research:

Berglind WJ, Case JM, Parker MP, Fuchs RA, See RE (2006) Dopamine D1 or D2 receptor antagonism within the basolateral amygdala differentially alters the acquisition of cocaine-cue associations necessary for cue-induced reinstatement of cocaine-seeking.  Neuroscience 137:699-706.

Fuchs RA, Branham RK, See RE (2006) Different neural substrates mediate cocaine seeking following abstinence versus extinction training: A critical role for the dorsolateral caudate-putamen.  Journal of Neuroscience 26(13):3584-3588.

Kippin TE, Fuchs RA, See RE (2006) Contributions of prolonged contingent and noncontingent cocaine exposure to enhanced reinstatement of cocaine-seeking in rats.  Psychopharmacology 187:60-67.

Fuchs RA, Feltenstein MW, See RE (2006) The role of the basolateral amygdala in stimulus-reward memory and extinction memory consolidation and in subsequent conditioned-cued reinstatement of cocaine seeking.  European Journal of Neuroscience 23:2809-2813.

Szumlinski, KK, KE Abernathy, EB Oleson, M Klugmann,  KD Lominac, D-Y He, D Ron, M During and  PW Kalivas. 2006. Homer isoforms differentially regulate cocaine-induced neuroplasticity. Neuropsychopharmacol, 31: 768-777.

Toda, S., H-W Shen, S Cagle and PW Kalivas.  2006.  Regulation of actin binding proteins contributes to cocaine-induced behavioral plasticity. J Neuroscience, 26: 1579-1587.

Peters, J and PW Kalivas. 2006. A role for nucleus accumbens group II metabotropic glutamate receptors in cocaine-induced reinstatement. Psychopharmacol, 186: 143-149.

Szumlinski, KK, PW Kalivas and PF Worley. 2006. Homer proteins:  implications for neuropsychiatric disorders. Curr Op Neurobiol, 16: 251-257.

Kalivas PW and XT Hu. 2006. Exciting inhibition in psychostimulant addiction. Tr Neurosci, 29:610-616.

Reviews of Literature:

Carr, D and PW Kalivas.  2006.  Orexin: A gate-keeper of addiction. Nat Medicine (News and Views), 12: 274-76.

Chapters in Books and Editorials:

Kalivas, PW and LM Cancela. 2006.  Hipotesis etiopatogenicas de los trastornos por abuso de sustancias.  In, Historia de la Psicofarmacologia.  Eds, F Lopez-Munoz and CA Gonzalez, pg 567-574.

Knackstedt LA and PW Kalivas. 2006. Pharmacotherapeutic targets for regulating cocaine-induced plasticity. Drugs of the Future, 31: 893-900.

Kalivas PW, J Peters and L Knackstedt. 2006. Animal models and brain circuits in drug addiction. Mol Interventions 6: 339-344.

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2005 Publications

Original Research:

Fuchs RA, Evans KA, Ledford CC, Parker MP, Case JM, Mehta RH, See RE (2005) The role of the mediodorsal prefrontal cortex, basolateral amygdala, and dorsal hippocampus in contextual reinstatement of cocaine seeking in rats. Neuropsychopharmacology 30(2):296-309Moran, M, K McFarland, RI Melendez, PW Kalivas and J Seamans. 2005. Cystine-glutamate exchange regulates synaptic transmission. J Neuroscience, 25: 6389-6393.

Kalivas, PW, N Volkow. 2005. The neural basis of addiction: A pathology of motivation and choice. Am J Psychiatry, 162: 1403-1413.

Tang, X-C, K McFarland, S Cagle and PW Kalivas.  2005.  The reinstatement of cocaine-seeking requires endogenous stimulation of mu opioid receptors.  J Neuroscience, 25: 4512-4520.

Melendez, R., J Vuthiganon and PW Kalivas.  2005.  Regulation of extracellular glutamate in the prefrontal cortex:  Focus on metabotropic glutamate receptors and cystine-glutamate exchange.  J Pharmacol Exp Ther, 314: 139-147.

Kalivas, PW, ND Volkow and J Seamans.  2005.  Unmanageable motivation in addiction:  A pathology in prefrontal-accumbens glutamate transmission. Neuron, 45: 647-650.

Reviews of Literature:

See RE (2005) Neural substrates of cocaine-cue associations that trigger relapse.  European Journal of Pharmacology 526:140-146.

Kalivas, PW. 2005. How do we determine which drug-induced neuroplastic changes are important? Nat Neuroscience (Perspective), 8: 1440-1441.

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2004 Publications

Original Research:

Fuchs RA, Evans KA, Parker MC, See RE (2004) Differential involvement of orbitofrontal cortex subregions in conditioned cue-induced and cocaine-primed reinstatement of cocaine seeking in rats. Journal of Neuroscience 24:6600-6610.

Fuchs RA, Evans KA, Parker MC, See RE (2004) Differential involvement of the core and shell subregions of the nucleus accumbens in conditioned cue-induced reinstatement of cocaine seeking in rats. Psychopharmacology 176:459-465.

McFarland K, SB Davidge, CC Lapish and PW Kalivas. 2004. Limbic and motor circuitry underlying footshock-induced reinstatement of cocaine-seeking behavior. J Neuroscience, 24: 1551-1560.

Bowers MS, K McFarland, RW Lake, YK Peterson, CC Lapish, ML Gregory, SM Lanier and PW Kalivas. 2004. Activator of G-protein signaling 3: A gatekeeper of cocaine sensitization and drug-seeking. Neuron, 42: 269-281.

Szumlinski, KK, MH Dehoff, S Kang, LD Middaugh, KA Frys, T Berry, PF Worley and PW Kalivas. 2004. Homer proteins regulate vulnerability to cocaine. Neuron, 43: 401-413.

Reviews of Literature:

Kalivas, PW. 2004. Glutamate systems and addiction. Curr Op Pharmacol, 4: 23-29.
Kalivas, PW. 2004. Recent understanding in the mechanisms of addiction. Curr Psychiat Rep, 6: 347-351.
Kalivas, PW and Volkow, N. 2004. The neural basis of addiction: A pathology of motivation and choice. Am J Psychiatry, in press.

Chapters in Books and Editorials:

Kalivas PW. 2004. Choose to study choice in addiction. Am J Psychiatry, 161: 193-194.

Melendez RI and PW Kalivas. 2004. Last call for adenosine transporters. Nat Neuroscience 7: 795-796.

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2003 Publications

Original Research:

See RE, McLaughlin J, Fuchs RA (2003) Muscarinic receptor blockade of the basolateral amygdala disrupts acquisition, but not expression, of conditioned reinstatement of cocaine-seeking behavior in rats.  Neuroscience 117:477-483.

McLaughlin J, See RE (2003) Selective inactivation of the dorsomedial prefrontal cortex and the basolateral amygdala attenuates conditioned-cued reinstatement of extinguished cocaine-seeking behavior in rats. Psychopharmacology 168:57-65.

Ledford CC, Fuchs RA, See RE (2003) Potentiated reinstatement of cocaine-seeking behavior following d-amphetamine infusion into the basolateral amygdala.  Neuropsychopharmacology 28(10):1721-1729.

Baker, DA, McFarland K, Lake RW, Shen H, Ghasemzadeh MB, Tang X, Toda S and PW Kalivas. 2003. Reduced extracellular glutamate and cystine-glutamate exchange underlie cocaine-seeking behavior Nat Neuroscience, 6: 743-749.

McFarland K, CC Lapish and PW Kalivas. 2003. Glutamate, not dopamine, in the accumbens core mediates cocaine-induced reinstatement of drug-seeking behavior. J Neuroscience, 23: 3531-3537.

Bowers MS and PW Kalivas. 2003. Forebrain astroglial plasticity is induced following withdrawal from repeated cocaine administration. Eur J Neuroscience, 17: 1273-8.

Ghasemzadeh, MB, LK Permenter, R Lake, PF Worley and PW Kalivas. 2003. Homer1 proteins and AMPA receptors regulate cocaine-induced behavioral plasticity. Eur J Neuroscience, 18: 1645-51.

Toda, S, LF Alguacil and PW Kalivas. 2003. Repeated cocaine administration changes the function and subcellular distribution of adenosine A1 receptors in the rat nucleus accumbens. J Neurochem, 87: 1478-1484.

Reviews of Literature:

See RE, Fuchs RA, Ledford CC, McLaughlin J (2003) Drug addiction, relapse, and the amygdala. Annals of the New York Academy of Sciences 985:294-307

Kalivas PW and K McFarland. 2003. Brain circuitry and the reinstatement of drug-seeking behavior. Psychopharmacology, 168: 44-56.

Chapters in Books and Editorials:

Kalivas PW, McFarland K, See RE (2003) Psychiatric pathophysiology: Addiction.  In: Psychiatry (Eds. Tasman A, Kay J, Lieberman JA), 2nd edition, Vol. 1, John Wiley & Sons, Chichester, England; pp. 330-337.

McFarland, K and PW Kalivas. 2003. Motivational circuitry. In: Handbook of Experimental Psychology. Vol 3, Biological Psychology, M Gallagher, RJ Nelson eds, Plenum Press, NY. 379-404.

Kalivas, PW, K McFarland and RE See. 2003. Psychiatric pathophysiology: Addiction. In: “Psychiatry, 2nd Edition”, A Tasman, J Kay, JA Lieberman (Eds), John Wiley & Sons, Ltd, Hoboken, NJ, 330-337.

Kalivas, PW. 2003. The development and expression of behavioral sensitization: Temporal profile of changes in gene expression. In “Molecular Biology of Drug Addiction”, R Moldanado (Ed), Humana Press, Totowa, NJ, 161-172.

Kalivas, P.W., Toda, S., Bowers, M.S., Baker, D.A. and Ghasemzadeh, M.B. 2003. The temporal sequence of changes in gene expression by drugs of abuse, in Drugs of Abuse: Neurological Reviews and Protocols, Ed. Wang, J.Q.,Humana Press, Totowa, New Jersey, 79: 3-11.

Crespo, JA, Crespo, JM Oliva, MB Ghasemzadeh, PW Kalivas and E Ambrosio. 2002. Neuroadaptative changes in NMDAR1 gene expression after extinction of cocaine self-administration". Ann. N. Y. Acad. Sci. 965: 78-91.

Kalivas, PW. 2003. Predisposition to addiction: Pharmacokinetics, pharmacodynamics and brain circuitry. Am J Psychiatry, 160: 1-3.

Kalivas, PW. 2003. Neuronal circuitry and cellular physiology mediating the reinstatement of drug seeking. In, Neuroscience of Drug Addiction: Focus on Neural Plasticity, M Massotti and L Pulvirenti, eds., Instituto Superiore di Sanita, Roma, IT, Rapporti ISTISAN, 03/7.

Baker DA and PW Kalivas. 2003. Sensitization and relapse: dopamine glutamate interactions. In, Dopamine and Glutamate in Psychiatric Disorders, Eds Maarten Reith and Werner J Schmidt. Humana Press Inc.

Kalivas PW, K McFarland, MS Bowers, K Szumlinski, ZX Xi and DA Baker. 2003. Glutamate transmission and addiction to cocaine. In: Glutamate and Disorders of Cognition and Motivation, Bita Moghaddam and Marina E Wolf, eds. Ann NY Acad Sci 1003: 169-175.

Baker DA, McFarland K, Lake RW, Shen H, Toda, S, and PW Kalivas. 2003. N-Acetyl cysteine-induced blockade of cocaine-induced reinstatement. Ann. N.Y. Acad. Sci. 1003: 349-351.

Bowers MS, Lake RW, McFarland K, Peterson YK, Lanier SM, Lapish CC, and PW Kalivas. 2003. AGS3: A G-protein regulator of addiction-associated behaviors. Ann. N.Y. Acad. Sci. 1003: 356-357.

Ghasemzadeh MB, Permenter LK, Lake RW, and PW Kalivas. 2003. Nucleus accumbens Homer proteins regulate behavioral sensitization to cocaine. Ann. N.Y. Acad. Sci. 1003: 395-397.

Bowers MS, Lake RW, Rubinchik S, Dong J-Y, and PW Kalivas. 2003. Elucidation of Homer 1a function in the nucleus accumbens using adenovirus gene transfer technology. Ann. N.Y. Acad. Sci. 1003: 419-421.

Szumlinski KK, Toda S, Middaugh LD, Worley PF, and PW Kalivas. 2003. Evidence for a relationship between Group 1 mGluR hypofunction and increased cocaine and ethanol sensitivity in Homer2 null mutant mice. Ann. N.Y. Acad. Sci. 1003: 468-471.

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