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Carroll A. Campbell, Jr. Neuropathology Laboratory (Brain Bank)


"Currently, there is no cure for Parkinson’s disease or Alzheimer's disease, and we are uniquely poised here at MUSC to bring forth novel treatment options for these conditions. South Carolina has a higher rate of dementia, obesity, and stroke than most states in our country, and the reason for this demography is not known. Examining brains from South Carolinians afflicted by these conditions will allow us to pinpoint, and hopefully remedy, this affliction in our state."        -  Dr. Lotta Granholm

Based on the significant momentum that has been built in the field of Alzheimer’s and Parkinson's disease research at MUSC, a neuropathology laborator, or “brain bank,” was established in 2009 where donated brains from the entire state could be processed and studied. The Carroll A. Campbell, Jr. Neuropathology Laboratory is named after former South Carolina Governor Carroll A. Campbell, Jr. who served as Governor from 1987 to 1995 and, at the age of 61, was diagnosed with Alzheimer’s disease. The CCNL is housed at the Medical University of South Carolina in Charleston, SC under the direction of Dr. Kumar Sambamurti and Dr. Lotta Granholm.

The CCNL serves as a statewide resource for patients, families, and researchers and will be the link between scientists and clinicians involved in aging research. The primary goal is to improve the diagnosis, care, and treatment of individuals suffering from neurological diseases; and, to accomplish this task, we must obtain brain tissue through donations from persons with neurological disorders, as well as those without, so that we may study the mechanisms responsible for these devastating illnesses. There is a great need for brain tissue from healthy older adults for comparison and for studies of normal aging-related changes in the brain.

The generous donation of brain tissue from thousands of donors around the country has helped establish many of the underlying causes of degeneration of the brain related to aging, but much work remains to be done before we can hope to develop treatment avenues that truly work.



The Carroll A. Campbell, Jr. Laboratory will generate a collection of well defined brain tissue from individuals with neurological disorders such as Alzheimer’s disease, Parkinson’s disease, cancer, stroke, and age-matched healthy brains in order to:
  • Provide valuable information about rate and cause for these disorders in South Carolina compared to other regions
  • Serve as a link between basic scientists and clinicians to generate translational research

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