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Thomas Dix, Ph.D.
Pilot Grant - Evaluation of Neurotensin Analogues for Cocaine Addiction
Our research addresses the development and exploitation of novel strategies of rational drug design, with a focus on peptide-based therapeutics. We have demonstrated dramatic improvements in the activities, stabilities, selectivities, and barrier-crossing efficiencies of peptide therapeutic candidates utilizing our strategies, which have been patented. Therapeutic candidates under current development include antipsychotic, analgesic and antibacterial peptides; our strategies can be applied to virtually any peptide of therapeutic interest. We also are developing biochemical tools such as receptor-specific peptide analogs, which then will be used to define the detailed physiological roles of individual members of receptor families.